3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyridine → 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-YL)pyrazolo(1, 5-A)pyrazine

HRID 1500764Notes

Reaction equation

HRID 1500764 reaction equation
Br[C:2]1[CH:3]=[N:4][N:5]2[CH:10]=[CH:9][N:8]=[CH:7][C:6]=12.[CH3:11][C:12]1([CH3:28])[C:16]([CH3:18])([CH3:17])[O:15][B:14](C2C=NN3C=CC=CC=23)[O:13]1>>[CH3:11][C:12]1([CH3:28])[C:16]([CH3:18])([CH3:17])[O:15][B:14]([C:2]2[CH:3]=[N:4][N:5]3[CH:10]=[CH:9][N:8]=[CH:7][C:6]=23)[O:13]1

Participants

3

Reactant 2

HCID 583859483-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyridineHCID 671237663-bromopyrazolo[1,5-a]pyrazine

Product 1

HCID 673722273-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-YL)pyrazolo(1, 5-A)pyrazine

Procedure

Obtained from 3-bromopyrazolo[1,5-a]pyrazine (Preparation 23c) following the experimental procedure as described in Preparation 27a, irradiating the reaction mixture at 100° C. for 1 h. The crude product was used without further purification in the next synthetic step.

Workup

  1. customirradiating the reaction mixture at 100° C. for 1 h
  2. customThe crude product was used without further purification in the next synthetic step

Sources & evidence

ORD record
ord-08a8de0563c54274995f2ad38eeb4d52
Source dataset
uspto-grants-2015_12
Patent number
US09206183B2

Reaction notes

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