3-(6-Chloropyrazin-2-yl)pyrazolo[1,5-a]pyridine → 3-(6-Chloropyrazin-2-yl)pyrazolo[1,5-a]pyrazine

HRID 1500765Notes

Reaction equation

HRID 1500765 reaction equation
CC1(C)C(C)(C)OB([C:9]2[CH:10]=[N:11][N:12]3[CH:17]=[CH:16][N:15]=[CH:14][C:13]=23)O1.[Cl:19][C:20]1[N:25]=[C:24](C2C=NN3C=CC=CC=23)[CH:23]=[N:22][CH:21]=1>>[Cl:19][C:20]1[N:25]=[C:24]([C:9]2[CH:10]=[N:11][N:12]3[CH:17]=[CH:16][N:15]=[CH:14][C:13]=23)[CH:23]=[N:22][CH:21]=1

Participants

3

Reactant 2

HCID 583034833-(6-Chloropyrazin-2-yl)pyrazolo[1,5-a]pyridineHCID 673722273-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-YL)pyrazolo(1, 5-A)pyrazine

Product 1

HCID 866917833-(6-Chloropyrazin-2-yl)pyrazolo[1,5-a]pyrazineYield 28%

Procedure

Obtained as a yellow solid (28% yield, two steps) from 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazolo[1,5-a]pyrazine (Preparation 29a) according to the experimental procedure as described in Preparation 27b followed by purification by flash chromatography (2:8 ethyl acetate/hexane).

Workup

  1. customfollowed by purification by flash chromatography (2:8 ethyl acetate/hexane)

Sources & evidence

ORD record
ord-203d7731093c42ae86e077e2fe7f80f1
Source dataset
uspto-grants-2015_12
Patent number
US09206183B2

Reaction notes

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