HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 86687878, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 86687880 | HCID 86687880 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 86687878 | HCID 86687878 | — |
Reaction Steps
Intermediate 60A (65 mg, 0.12 mmol) was stirred in 1 ml of a 4 M solution of hydrogen chloride in 1,4-dioxane for 2 h at rt. The suspension was evaporated to dryness, and the crude product was purified by preparative RP-HPLC (Reprosil C18, gradient 10-95% acetonitrile/0.1% aq. hydrochloric acid) affording 49 mg (74% of th.) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206184B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-39fbf61a8e104539a36885491719346e |
| Source note | uspto-grants-2015_12 |