Hydrochloric Acid → HCID 86687878, compound

HRID 1500816Notes

Reaction equation

HRID 1500816 reaction equation
[NH2:1][C:2]1[C:7]2=[C:8]([C:26]3[S:27][C:28]4[C:34]([O:35][CH3:36])=[CH:33][C:32]([CH3:37])=[CH:31][C:29]=4[CH:30]=3)[C:9]([Cl:25])=[C:10]([CH2:11][N:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[N:6]2[N:5]=[CH:4][N:3]=1.[ClH:38]>O1CCOCC1>[ClH:25].[ClH:38].[ClH:25].[Cl:25][C:9]1[C:8]([C:26]2[S:27][C:28]3[C:34]([O:35][CH3:36])=[CH:33][C:32]([CH3:37])=[CH:31][C:29]=3[CH:30]=2)=[C:7]2[N:6]([C:10]=1[CH2:11][N:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1)[N:5]=[CH:4][N:3]=[C:2]2[NH2:1]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86687880HCID 86687880, compound

Product 1

HCID 86687878HCID 86687878, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Intermediate 60A (65 mg, 0.12 mmol) was stirred in 1 ml of a 4 M solution of hydrogen chloride in 1,4-dioxane for 2 h at rt. The suspension was evaporated to dryness, and the crude product was purified by preparative RP-HPLC (Reprosil C18, gradient 10-95% acetonitrile/0.1% aq. hydrochloric acid) affording 49 mg (74% of th.) of the title compound.

Workup

  1. customThe suspension was evaporated to dryness
  2. customthe crude product was purified by preparative RP-HPLC (Reprosil C18, gradient 10-95% acetonitrile/0.1% aq. hydrochloric acid)

Sources & evidence

ORD record
ord-39fbf61a8e104539a36885491719346e
Source dataset
uspto-grants-2015_12
Patent number
US09206184B2

Reaction notes

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