Methanol → HCID 178501320, compound

HRID 1500889Notes

Reaction equation

HRID 1500889 reaction equation
[NH2:1][C@H:2]1[CH2:5][C@H:4]([C:6]([OH:8])=[O:7])[CH2:3]1.O=S(Cl)[Cl:11].[CH3:13]O>>[ClH:11].[NH2:1][C@H:2]1[CH2:5][C@H:4]([C:6]([O:8][CH3:13])=[O:7])[CH2:3]1

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 178511730HCID 178511730, compound

Product 1

HCID 178501320HCID 178501320, compound

Conditions

Temperature
100 °C

Procedure

To a solution of trans-3-aminocyclobutanecarboxylic acid (500 mg, 3.3 mmol) in MeOH (20 mL) was added SOCl2 dropwise at 0° C. The resulting mixture was heated at 100° C. for 4 hours and then concentrated in vacuo to afford the crude methyl trans-3-aminocyclobutanecarboxylate hydrochloride which was used in the next step directly.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-495aab1d0a08460aae40e648a95f6e5f
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

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