Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 178511730 | HCID 178511730 | — |
| Product | HCID 178501320 | HCID 178501320 | — |
Reaction Steps
To a solution of trans-3-aminocyclobutanecarboxylic acid (500 mg, 3.3 mmol) in MeOH (20 mL) was added SOCl2 dropwise at 0° C. The resulting mixture was heated at 100° C. for 4 hours and then concentrated in vacuo to afford the crude methyl trans-3-aminocyclobutanecarboxylate hydrochloride which was used in the next step directly.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09206191B2 |
|---|
| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-495aab1d0a08460aae40e648a95f6e5f |
|---|
| Source note | uspto-grants-2015_12 |
|---|
