Trifluoroacetic acid → HCID 178459280, compound

HRID 1500890Notes

Reaction equation

HRID 1500890 reaction equation
[OH:1][C:2]([C@H:5]1[CH2:8][C@H:7]([NH:9]C(=O)OC(C)(C)C)[CH2:6]1)([CH3:4])[CH3:3].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:9][C@H:7]1[CH2:8][C@H:5]([C:2]([OH:1])([CH3:4])[CH3:3])[CH2:6]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178454086HCID 178454086, compound

Product 1

HCID 178459280HCID 178459280, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of tert-butyl [trans-3-(2-hydroxypropan-2-yl)cyclobutyl]carbamate (250 mg, 1.09 mmol) and TFA (10 mL) in DCM (10 mL) was stirred at RT for 2 hours. The resulting mixture was then concentrated in vacuo to afford 2-(trans-3-aminocyclobutyl)propan-2-ol which was used in the next step directly.

Workup

  1. concentrationThe resulting mixture was then concentrated in vacuo

Sources & evidence

ORD record
ord-5d9ae5e3680241b1a63dba18dae33163
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

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