Ethanol → HCID 178472515, compound

HRID 1500942Notes

Reaction equation

HRID 1500942 reaction equation
Cl.[NH2:2][C@H:3]1[CH2:6][C@H:5]([C:7]([OH:9])=[O:8])[CH2:4]1.O=S(Cl)[Cl:12].[CH3:14][CH2:15]O>>[ClH:12].[NH2:2][C@H:3]1[CH2:6][C@H:5]([C:7]([O:9][CH2:14][CH3:15])=[O:8])[CH2:4]1

Participants

4

Reactant 3

HCID 702EthanolHCID 24386Thionyl ChlorideHCID 178479280HCID 178479280, compound

Product 1

HCID 178472515HCID 178472515, compound

Conditions

Temperature
100 °C

Procedure

To a solution of trans-3-aminocyclobutanecarboxylic acid hydrochloride (1.0 g, 6.5 mmol) in 20 mL of EtOH was added 10 mL of SOCl2 dropwise at 0° C. The resulting mixture was heated with stirring at 100° C. for 16 hours. And then, the solvent was evaporated to afford the residue which was used in the next step directly.

Workup

  1. temperatureThe resulting mixture was heated
  2. customAnd then, the solvent was evaporated
  3. customto afford the residue which

Sources & evidence

ORD record
ord-e880b4739f6b4eb7b78e4ec8902e36a8
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

Loading…