4-[(2-Amino-4-chlorophenyl)amino]-1,1,1-trifluoro-2-methylbutan-2-ol → 4-(5-chloro-2-{[3-(methylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl]methyl}-1H-benzimidazol-1-yl)-1,1,1-trifluoro-2-methylbutan-2-ol

HRID 1500950Notes

Reaction equation

HRID 1500950 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[NH:9][CH2:10][CH2:11][C:12]([CH3:18])([OH:17])[C:13]([F:16])([F:15])[F:14].[CH3:19][S:20]([C:23]1[C:31]2[C:26](=[CH:27][N:28]=[CH:29][CH:30]=2)[NH:25][N:24]=1)(=[O:22])=[O:21].CS([C:36]1[C:44]2C(=CC=CC=2)NN=1)(=O)=O>>[Cl:8][C:6]1[CH:5]=[CH:4][C:3]2[N:9]([CH2:10][CH2:11][C:12]([CH3:18])([OH:17])[C:13]([F:16])([F:14])[F:15])[C:36]([CH2:44][N:25]3[C:26]4=[CH:27][N:28]=[CH:29][CH:30]=[C:31]4[C:23]([S:20]([CH3:19])(=[O:22])=[O:21])=[N:24]3)=[N:1][C:2]=2[CH:7]=1

Participants

4

Reactant 3

HCID 899238924-[(2-Amino-4-chlorophenyl)amino]-1,1,1-trifluoro-2-methylbutan-2-olHCID 1785048563-methanesulfonyl-1H-indazoleHCID 178504858HCID 178504858, compound

Product 1

HCID 729489004-(5-chloro-2-{[3-(methylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl]methyl}-1H-benzimidazol-1-yl)-1,1,1-trifluoro-2-methylbutan-2-ol

Procedure

The title compound was prepared in analogy to Example 2-1 by using 4-[(2-amino-4-chlorophenyl)amino]-1,1,1-trifluoro-2-methylbutan-2-ol and 3-(methylsulfonyl)-1H-pyrazolo[3,4-c]pyridine instead of 4-chloro-N—((R)-1,1-dioxo-tetrahydro-1λ6-thiophen-3-yl)-benzene-1,2-diamine and 3-methanesulfonyl-1H-indazole.

Sources & evidence

ORD record
ord-8c54fd4fd9d4423098f48e67bdadcadf
Source dataset
uspto-grants-2015_12
Patent number
US09206191B2

Reaction notes

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