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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1500950Generated: November 1, 2026

4-[(2-Amino-4-chlorophenyl)amino]-1,1,1-trifluoro-2-methylbutan-2-ol → 4-(5-chloro-2-{[3-(methylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl]methyl}-1H-benzimidazol-1-yl)-1,1,1-trifluoro-2-methylbutan-2-ol

https://huagongshe.com/reaction/1500950

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-[(2-Amino-4-chlorophenyl)amino]-1,1,1-trifluoro-2-methylbutan-2-olHCID 89923892—
Reactant3-methanesulfonyl-1H-indazoleHCID 178504856—
ReactantHCID 178504858HCID 178504858—
Product4-(5-chloro-2-{[3-(methylsulfonyl)-1H-pyrazolo[3,4-c]pyridin-1-yl]methyl}-1H-benzimidazol-1-yl)-1,1,1-trifluoro-2-methylbutan-2-olHCID 72948900—

Reaction Steps

The title compound was prepared in analogy to Example 2-1 by using 4-[(2-amino-4-chlorophenyl)amino]-1,1,1-trifluoro-2-methylbutan-2-ol and 3-(methylsulfonyl)-1H-pyrazolo[3,4-c]pyridine instead of 4-chloro-N—((R)-1,1-dioxo-tetrahydro-1λ6-thiophen-3-yl)-benzene-1,2-diamine and 3-methanesulfonyl-1H-indazole.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09206191B2
Source datasetuspto-grants-2015_12
ORD IDord-8c54fd4fd9d4423098f48e67bdadcadf
Source noteuspto-grants-2015_12