反应详情

温度

130 °C

To a solution of methyl 4-fluoro-3-methylbenzoate (1.7 g, 10 mmol) and 2-bromo-3-ethylphenol (2.0 g, 10 mmol) in dimethyl sulfoxide (10 mL) was added potassium carbonate (2.8 g, 20 mmol). The reaction mixture was stirred at 130° C. for 3 hours. After the reaction, the mixture was poured into water (50 mL) and the solution was extracted with ethyl acetate (50 mL), washed with water (50 mL). The organic phase was dried over anhydrous sodium sulfate. The mixture was filtered and the solvent was removed under reduced pressure to give the pure product methyl 4-(2-bromo-3-ethylphenoxy)-3-methylbenzoate as colorless oil (2.10 g, 60%).

1. customAfter the reaction
2. extractionthe solution was extracted with ethyl acetate (50 mL)
3. washwashed with water (50 mL)
4. dry with materialThe organic phase was dried over anhydrous sodium sulfate
5. filtrationThe mixture was filtered
6. customthe solvent was removed under reduced pressure