反应详情

To a solution of 4-fluoro-2-methoxybenzoic acid (1.7 g, 10 mmol) in methanol (100 mL) was added thionyl chloride (5.73 g, 48 mmol) at 0° C. The resultant mixture was stirred for 12 hours and then solvent was evaporated in vacuo. To the residue, saturated sodium bicarbonate aqueous solution (50 mL) was added and the mixture was extracted with ethyl acetate (100 mL×3). The organic phase was dried by sodium sulfate. The mixture was filtered and the filtrate was concentrated in vacuo to give methyl 4-fluoro-2-methoxybenzoate (1.3 g, 70%).

1. customsolvent was evaporated in vacuo
2. additionTo the residue, saturated sodium bicarbonate aqueous solution (50 mL) was added
3. extractionthe mixture was extracted with ethyl acetate (100 mL×3)
4. dry with materialThe organic phase was dried by sodium sulfate
5. filtrationThe mixture was filtered
6. concentrationthe filtrate was concentrated in vacuo