反应详情

Lithium hydroxide (54 mg, 2.24 mmol) was added to a solution of methyl 4-(1-(o-tolyloxy)ethyl)benzoate (151 mg, 0.56 mmol) in methanol (100 mL) and water (10 mL). The reaction mixture was stirred at room temperature for 3 hours. After the reaction, the solvent was removed in vacuo. 3 mol/L aqueous hydrogen chloride was added to make pH 2˜3, and the product was extracted with dichloromethane (100 mL*3) The combined organic phase was washed with Sodium Chloride (20 mL*3), dried over anhydrous sodium sulfate, and the solvent was evaporated to dryness to give 4-(1-(o-tolyloxy)ethyl)benzoic acid (127 mg, 88%).

1. customAfter the reaction
2. customthe solvent was removed in vacuo
3. addition3 mol/L aqueous hydrogen chloride was added
4. extractionthe product was extracted with dichloromethane (100 mL*3) The combined organic phase
5. washwas washed with Sodium Chloride (20 mL*3)
6. dry with materialdried over anhydrous sodium sulfate
7. customthe solvent was evaporated to dryness