反应详情

To a solution of tert-butyl 4-(2,3-dihydrobenzofuran-2-yl)benzoate (0.03 g, 0.1 mmol) in dichloromethane (3.0 mL) was added trifluoroacetic acid (1.0 mL). The reaction mixture was stirred at room temperature for 1 hour. After the reaction, the solvent was removed in vacuo, and the mixture was dissolved in dichloromethane (50 mL), washed with water (50 mL). The organic phase was dried over anhydrous sodium sulfate and filtered. The solvent was removed in vacuo to give pure product 4-(2,3-dihydrobenzofuran-2-yl)benzoic acid as a white solid (0.02 g, 80%).

1. customAfter the reaction
2. customthe solvent was removed in vacuo
3. dissolutionthe mixture was dissolved in dichloromethane (50 mL)
4. washwashed with water (50 mL)
5. dry with materialThe organic phase was dried over anhydrous sodium sulfate
6. filtrationfiltered
7. customThe solvent was removed in vacuo