反应详情

To a solution of ethyl 2-phenoxypyrimidine-5-carboxylate (400 mg, 1.6 mmol) in mixed solution of tetrahydrofuran/methanol/water=3:1:1 (4 mL) was added lithium hydroxide monohydrate (200 mg, 8.4 mmol). The mixture was stirred at room temperature for 2 hours. The suspension was concentrated in vacuo. To the residue, was added water (50 mL) and extracted with dichloromethane (2*50 mL). The combined organic phase was separated, dried by sodium sulfate, filtered and concentrated to give a residue. The residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate=5/1) to give the product 2-phenoxypyrimidine-5-carboxylic acid (300 mg, 79%) as pale solid.

1. concentrationThe suspension was concentrated in vacuo
2. additionTo the residue, was added water (50 mL)
3. extractionextracted with dichloromethane (2*50 mL)
4. customThe combined organic phase was separated
5. dry with materialdried by sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. customto give a residue
9. customThe residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate=5/1)