Hydrochloric Acid → HCID 89581262, compound

Participants

Reaction Steps

A suspension solution of methyl 6-(1-phenoxyethyl)pyridazine-3-carboxylate (0.1 g, 0.4 mmol) and lithium hydroxide (48 mg, 2 mmol) in tetrahydrofuran (20 mL) and water (10 mL) was stirred at room temperature for 2 hours. The mixture solution was diluting with ethyl acetate (50 mL), and acidified with hydrochloric acid to PH<5. The organic layer was separated, dried over sodium sulfate, and concentrated to give 6-(1-phenoxyethyl)pyridazine-3-carboxylic acid (60 mg, 65%) which was used directly for the next step without purification.

Provenance & Evidence