Hydrochloric Acid → HCID 89581262, compound

HRID 1501250Notes

Reaction equation

HRID 1501250 reaction equation
[O:1]([CH:8]([C:10]1[N:15]=[N:14][C:13]([C:16]([O:18]C)=[O:17])=[CH:12][CH:11]=1)[CH3:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Li+].Cl>O1CCCC1.O.C(OCC)(=O)C>[O:1]([CH:8]([C:10]1[N:15]=[N:14][C:13]([C:16]([OH:18])=[O:17])=[CH:12][CH:11]=1)[CH3:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 89581070HCID 89581070, compound

Product 1

HCID 89581262HCID 89581262, compoundYield 65%

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

A suspension solution of methyl 6-(1-phenoxyethyl)pyridazine-3-carboxylate (0.1 g, 0.4 mmol) and lithium hydroxide (48 mg, 2 mmol) in tetrahydrofuran (20 mL) and water (10 mL) was stirred at room temperature for 2 hours. The mixture solution was diluting with ethyl acetate (50 mL), and acidified with hydrochloric acid to PH<5. The organic layer was separated, dried over sodium sulfate, and concentrated to give 6-(1-phenoxyethyl)pyridazine-3-carboxylic acid (60 mg, 65%) which was used directly for the next step without purification.

Workup

  1. customThe organic layer was separated
  2. dry with materialdried over sodium sulfate
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-83316cb00d0e437a8c290e8dda15495d
Source dataset
uspto-grants-2015_12
Patent number
US09206128B2

Reaction notes

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