反应详情

温度

0 °C

A mixture of tert-butyl {1-[4-(phenylacetyl)phenyl]cyclobutyl}carbamate (5.0 g, 13.68 mmol, 1.0 eq) and pyridinium hydrobromide perbromide (4.38 g, 13.68 mmol, 1.0 eq) in THF (78 mL) was stirred at 0° C. for 30 minutes. The mixture was partitioned between EtOAc and water and the organic phase washed respectively with aqueous sodium thiosulfate solution and brine, dried, filtered through a silicone coated filter paper and concentrated in vacuo to give the crude title compound (5.44 g, 93% purity by UPLC-MS) which was used without further purification.

1. customThe mixture was partitioned between EtOAc and water
2. washthe organic phase washed respectively with aqueous sodium thiosulfate solution and brine
3. customdried
4. filtrationfiltered through a silicone coated filter paper
5. concentrationconcentrated in vacuo