Tert-butyl 3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate → 2-(5-Oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-3-one

HRID 1501766Notes

Reaction equation

HRID 1501766 reaction equation
C(OC([N:8]1[CH2:18][CH2:17][C:11]2([CH2:15][NH:14][C:13](=[O:16])[CH2:12]2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)S(O[C:25]1[CH2:26][O:27][C:28](=[O:31])[C:29]=1C)(=O)=O.CC1C(=O)OCC=1N1CCCC2(CCNCC2)C1=O>>[O:31]=[C:28]1[O:27][CH2:26][C:25]([N:14]2[C:13](=[O:16])[CH2:12][C:11]3([CH2:10][CH2:9][NH:8][CH2:18][CH2:17]3)[CH2:15]2)=[CH:29]1

Participants

4

Reactant 3

HCID 10015184Tert-butyl 3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylateHCID 108901884-Methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonateHCID 86709456HCID 86709456, compound

Product 1

HCID 867094542-(5-Oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-3-one

Procedure

The title compound was prepared from 3-oxo-2,8-diaza-spiro[4,5]decane-8-carboxylic acid tert-butyl ester and 4-methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate in two steps in an analogous fashion to that described for 2-(4-Methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,9-diazaspiro[5.5]undecan-1-one (I-19) above.

Sources & evidence

ORD record
ord-66d34e48c2484fd8914f7c7fc680188d
Source dataset
uspto-grants-2015_12
Patent number
US09206198B2

Reaction notes

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