Tert-butyl 3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate → 2-(5-Oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-3-one

Participants

Role	Name	HCID	Charge
Reactant	Tert-butyl 3-oxo-2,8-diazaspiro[4.5]decane-8-carboxylate	HCID 10015184	—
Reactant	4-Methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate	HCID 10890188	—
Reactant	HCID 86709456	HCID 86709456	—
Product	2-(5-Oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-3-one	HCID 86709454	—

Reaction Steps

The title compound was prepared from 3-oxo-2,8-diaza-spiro[4,5]decane-8-carboxylic acid tert-butyl ester and 4-methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate in two steps in an analogous fashion to that described for 2-(4-Methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,9-diazaspiro[5.5]undecan-1-one (I-19) above.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09206198B2
Source dataset	uspto-grants-2015_12
ORD ID	ord-66d34e48c2484fd8914f7c7fc680188d
Source note	uspto-grants-2015_12