反应详情

A mixture of intermediate (5) (0.25 mol) and KOH (1 mol) in water (650 ml) was stirred and refluxed for 2 hours. The reaction mixture was cooled, acidified with HCl and the resulting precipitate was filtered off, washed with water, and dried, yielding 48 g of 8-chloro-3,4-dihydro-2H-1,5-benzodioxepin-6-carboxylic acid (intermediate 6).

1. temperaturerefluxed for 2 hours
2. temperatureThe reaction mixture was cooled
3. filtrationthe resulting precipitate was filtered off
4. washwashed with water
5. customdried