反应详情

To a flask charged with 2-chloro-3-(hydroxymethyl)phenol and a stir bar was added NBS (10.8 g, 60.5 mmol) and TFA (50 mL). The reaction was allowed to stir for 16 hours at RT, then the solvent was removed under vacuum. The residue was re-dissolved in EtOAc, washed with water, and purified by silica gel flash chromatography. A pair of regio-isomers was collected from the separation. The less polar spot was the desired 4-bromo-2-chloro-3-(hydroxymethyl)phenol according to NMR analysis.

1. customthe solvent was removed under vacuum
2. dissolutionThe residue was re-dissolved in EtOAc
3. washwashed with water
4. custompurified by silica gel flash chromatography
5. customA pair of regio-isomers was collected from the separation