HCID 117690302, compound → HCID 89633494, compound

HRID 1501968Notes

Reaction equation

HRID 1501968 reaction equation
[CH3:1][C@@H:2]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C@@H:12]3[CH2:17][N:16]4[CH2:18][CH2:19][N:20](C(OCC5C=CC=CC=5)=O)[CH2:21][C@H:15]4[CH2:14][N:13]3[C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH:9]=2)[C:4](=[O:39])[O:3]1>CO.[Pd]>[CH3:1][C@@H:2]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C@@H:12]3[CH2:17][N:16]4[CH2:18][CH2:19][NH:20][CH2:21][C@H:15]4[CH2:14][N:13]3[C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[CH:9]=2)[C:4](=[O:39])[O:3]1

Participants

4

Reactant 1

HCID 117690302HCID 117690302, compound

Product 1

HCID 89633494HCID 89633494, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To the solution of (3R,9aS)-8-benzyl 2-tert-butyl 3-((R)-3-methyl-1-oxoisochroman-6-yl)tetrahydro-1H-pyrazino[1,2-a]pyrazine-2,8(9H,9aH)-dicarboxylate (0.590 g, 1.10 mmol) in methanol (20 mL) was added palladium on carbon (10%, 0.117 g, 0.110 mmol) and the mixture was subjected to hydrogenation at rt overnight. After filtration the filtrate was concentrated to give the title compound.

Workup

  1. filtrationAfter filtration the filtrate
  2. concentrationwas concentrated

Sources & evidence

ORD record
ord-534b28a1a483474aa4dd8f41130a3204
Source dataset
uspto-grants-2015_12
Patent number
US09206199B2

Reaction notes

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