反应详情

tert-Butyl 3-(2-methoxy-2-oxoethyl)piperazine-1-carboxylate (7.28 g, 28.2 mmol) was dissolved in THF (100 mL) at 0° C. then added LAH (21.14 mL, 21.14 mmol). The reaction was monitored by TLC. After 30 mins, the reaction was first quenched with 0.8 mL water, then added 1.6 mL 2N NaOH followed by 4 mL water. The above slurry was diluted with ethyl acetate and MgSO4 was added. The mixture was stirred at RT for ½ h, then filtered and concentrated to yield the title compound: LC-MS (IE, m/z): 231 [M+1]+.

1. customthe reaction was first quenched with 0.8 mL water
2. additionadded 1.6 mL 2N NaOH
3. additionThe above slurry was diluted with ethyl acetate and MgSO4
4. additionwas added
5. filtrationfiltered
6. concentrationconcentrated