m-Chloroperbenzoic acid → HCID 89619371, compound

HRID 1502076Notes

Reaction equation

HRID 1502076 reaction equation
F[C:2]1[CH:9]=[C:8](C=C)[CH:7]=[C:6]([O:12][CH3:13])[C:3]=1[C:4]#[N:5].C1C=C(Cl)C=[C:16]([C:21]([O:23]O)=O)C=1.[F:25]C1C(C2CO2)=CC(OC)=C(C=1)C#N>>[F:25][C:8]1[C:9]([CH:16]2[CH2:21][O:23]2)=[CH:2][C:3]([C:4]#[N:5])=[C:6]([O:12][CH3:13])[CH:7]=1

Participants

4

Reactant 3

HCID 70297m-Chloroperbenzoic acidHCID 866473025-Fluoro-2-methoxy-4-oxiran-2-ylbenzonitrileHCID 89618927HCID 89618927, compound

Product 1

HCID 89619371HCID 89619371, compound

Procedure

4-Fluoro-2-methoxy-5-(oxiran-2-yl)benzonitrile was prepared from 2-fluoro-6-methoxy-4-vinylbenzonitrile using m-CPBA in an analagous fashion to that described for 5-fluoro-2-methoxy-4-(oxiran-2-yl)benzonitrile (Step H) above: LC/MS: [(M+1)]+=194

Sources & evidence

ORD record
ord-e99a25d2db4545469ebc89798dc80aa9
Source dataset
uspto-grants-2015_12
Patent number
US09206199B2

Reaction notes

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