HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-fluoro-2-methyl-3-((3R,9aR)-octahydropyrazino[2,1-c][1,4]oxazin-3-yl)benzonitrile → (3R,9aR)-tert-Butyl 3-(3-cyano-4-fluoro-2,5-dimethylphenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-fluoro-2-methyl-3-((3R,9aR)-octahydropyrazino[2,1-c][1,4]oxazin-3-yl)benzonitrile | HCID 71273584 | — |
| Reactant | (3R,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2,5-dimethylphenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate | HCID 89633504 | — |
| Product | (3R,9aR)-tert-Butyl 3-(3-cyano-4-fluoro-2,5-dimethylphenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate | HCID 89633507 | — |
Reaction Steps
(3R,9aR)-tert-Butyl 3-(3-cyano-4-fluoro-2,5-dimethylphenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate was prepared in an analogous fashion to that described for the synthesis of (3R,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2,5-dimethylphenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate starting from 6-fluoro-2-methyl-3-((3R,9aR)-octahydropyrazino[2,1-c][1,4]oxazin-3-yl)benzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206199B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-31ae8fb618ad4aef953d9c043a2ddad8 |
| Source note | uspto-grants-2015_12 |