Hydrochloric Acid → HCID 117690295, compound

HRID 1502099Notes

Reaction equation

HRID 1502099 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C@H:9]2[O:14][CH2:13][C@@H:12]3[CH2:15][N:16](C(OC(C)(C)C)=O)[CH2:17][CH2:18][N:11]3[CH2:10]2)=[CH:5][C:4]=1[O:26][CH3:27])#[N:2].[ClH:28]>O1CCOCC1>[ClH:28].[CH3:27][O:26][C:4]1[CH:5]=[C:6]([C@H:9]2[O:14][CH2:13][C@@H:12]3[CH2:15][NH:16][CH2:17][CH2:18][N:11]3[CH2:10]2)[CH:7]=[CH:8][C:3]=1[C:1]#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71273535HCID 71273535, compound

Product 1

HCID 117690295HCID 117690295, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl (3R,9aS)-3-(4-cyano-3-methoxyphenyl)hexahydropyrazino[2,1-c][1,4]oxazine-8(1H)-carboxylate (90.0 mg, 0.241 mmol) was dissolved in 5 mL of 4 M HCl in dioxane and stirred at room temperature for 8 h. The mixture was concentrated to ¼ the original volume and diluted with 10 mL of diethyl ether. The precipitate was filtered and dried under high vacuum to offer

Workup

  1. concentrationThe mixture was concentrated
  2. additiondiluted with 10 mL of diethyl ether
  3. filtrationThe precipitate was filtered
  4. customdried under high vacuum

Sources & evidence

ORD record
ord-12083eb5e45340afba2ca305fa12e73f
Source dataset
uspto-grants-2015_12
Patent number
US09206199B2

Reaction notes

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