2-Chloro-3-methoxy-5-nitropyridine → 2-(3-methoxy-5-(1H-tetrazol-1-yl)pyridin-2-yl)acetic acid

HRID 1502112Notes

Reaction equation

HRID 1502112 reaction equation
N1(C2N=CC(C[C:13](O)=[O:14])=CC=2)C=NN=N1.[N:16]1([C:21]2[CH:22]=[CH:23][C:24]([CH2:27][C:28]([OH:30])=[O:29])=[N:25][CH:26]=2)[CH:20]=[N:19][N:18]=[N:17]1.ClC1C(OC)=CC([N+]([O-])=O)=CN=1>>[CH3:13][O:14][C:23]1[C:24]([CH2:27][C:28]([OH:30])=[O:29])=[N:25][CH:26]=[C:21]([N:16]2[CH:20]=[N:19][N:18]=[N:17]2)[CH:22]=1

Participants

4

Reactant 3

HCID 234561522-Chloro-3-methoxy-5-nitropyridineHCID 66524945[6-(1H-Tetrazol-1-yl)pyridine-3-yl]acetic acidHCID 675176762-(5-(1H-tetrazol-1-yl)pyridin-2-yl)acetic acid

Product 1

HCID 896189802-(3-methoxy-5-(1H-tetrazol-1-yl)pyridin-2-yl)acetic acid

Procedure

The title compound was prepared in an analagous fashion to that described for the syntheses of [6-(1H-tetrazol-1-yl)pyridin-3-yl]acetic acid (Method 1, Steps B-F and [5-(1H-tetrazol-1-yl)pyridin-2-yl]acetic acid (Steps A-E) starting from 2-chloro-3-methoxy-5-nitropyridine. LC/MS: [(M+1-28)]+=208.2.

Sources & evidence

ORD record
ord-b1c66e2c559f4f32b0b97db5e2db7c91
Source dataset
uspto-grants-2015_12
Patent number
US09206199B2

Reaction notes

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