Phenyl chloroformate → phenyl[6-(1H-tetrazol-1-yl)pyridin-3-yl]carbamate

HRID 1502169Notes

Reaction equation

HRID 1502169 reaction equation
[N:1]1([C:6]2[N:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=2)[CH:5]=[N:4][N:3]=[N:2]1.Cl[C:14]([O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:15]>N1C=CC=CC=1>[C:17]1([O:16][C:14](=[O:15])[NH:12][C:9]2[CH:10]=[N:11][C:6]([N:1]3[CH:5]=[N:4][N:3]=[N:2]3)=[CH:7][CH:8]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 15891Phenyl chloroformateHCID 669273386-(1H-1,2,3,4-tetrazol-1-yl)pyridin-3-amine

Product 1

HCID 117693882phenyl[6-(1H-tetrazol-1-yl)pyridin-3-yl]carbamate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

6-(1H-Tetrazol-1-yl)pyridin-3-amine (50 mg, 0.308 mmol) was dissolved in pyridine (1.5 mL), followed by addition of phenyl chloroformate (53.1 mg, 0.339 mmol). The mixture was stirred at RT overnight, and was concentrated to give crude title compound. LC/MS: [(M+1]+=283.14, [(M+1-28)]+=255.13.

Workup

  1. concentrationwas concentrated

Sources & evidence

ORD record
ord-d7d74cbc5d9748959ebd48eaa2c052e5
Source dataset
uspto-grants-2015_12
Patent number
US09206199B2

Reaction notes

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