Dichloromethane → Trifluoroacetic acid

HRID 150258Notes

Reaction equation

HRID 150258 reaction equation
[Cl:1][c:2]1[c:3]([CH:9]2[N:10]([c:14]3[n:15][c:16]4[n:17]([cH:18][cH:19]3)[n:20][cH:21][c:22]4[NH:23][C:24](=[O:25])[CH:26]3[CH2:27][N:28]([C:30]([O:31][C:32]([CH3:33])([CH3:34])[CH3:35])=[O:36])[CH2:29]3)[CH2:11][CH2:12][CH2:13]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1.[Cl:44][CH2:45][Cl:46].[F:37][C:38]([C:39](=[O:40])[OH:41])([F:42])[F:43]>>[Cl:1][c:2]1[c:3]([CH:9]2[N:10]([c:14]3[n:15][c:16]4[n:17]([cH:18][cH:19]3)[n:20][cH:21][c:22]4[NH:23][C:24](=[O:25])[CH:26]3[CH2:27][NH:28][CH2:29]3)[CH2:11][CH2:12][CH2:13]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1.[F:37][C:38]([C:39](=[O:40])[OH:41])([F:42])[F:43]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 67328786Tert-butyl 3-[[5-[2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]carbamoyl]azetidine-1-carboxylate

Product 2

HCID 6422Trifluoroacetic acidHCID 67329317N-[5-[2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl]pyrazolo[1,5-a]pyrimidin-3-yl]azetidine-3-carboxamide

Sources & evidence

ORD record
ord-3e58882743b34a27b87275918bb6e3b6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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