Hydrochloric Acid → Sodium hydroxide rebamipide

HRID 1502599Notes

Reaction equation

HRID 1502599 reaction equation
Cl.[OH-].[Na+:3].[CH:4]1[CH:5]=[CH:6][C:7]2[NH:14][C:12](=[O:13])[CH:11]=[C:10]([CH2:15][CH:16]([NH:20][C:21]([C:23]3[CH:24]=[CH:25][C:26]([Cl:29])=[CH:27][CH:28]=3)=[O:22])[C:17]([OH:19])=[O:18])[C:8]=2[CH:9]=1>O>[OH-:13].[Na+:3].[CH:4]1[CH:5]=[CH:6][C:7]2[NH:14][C:12](=[O:13])[CH:11]=[C:10]([CH2:15][CH:16]([NH:20][C:21]([C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)=[O:22])[C:17]([OH:19])=[O:18])[C:8]=2[CH:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5042RebamipideHCID 14798Sodium Hydroxide2×

Product 1

HCID 68327531Sodium hydroxide rebamipide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

12 mL of 10 N hydrochloric acid (14.2 g, 0.12 mol), 68 mL of purified water, and 200 mL of an aqueous solution of 5% (w/v) HPMC (TC-5E) were mixed to prepare a hydrochloric acid-HPMC (TC-5E) solution. To 700 mL of an aqueous solution of sodium hydroxide which was prepared by adding purified water to 4.4 g of sodium hydroxide (0.11 mol), 20 g of rebamipide (0.054 mol) was added and dissolved with heating to give a sodium hydroxide-rebamipide solution.

Workup

  1. additionby adding
  2. additionwas added
  3. dissolutiondissolved
  4. temperaturewith heating

Sources & evidence

ORD record
ord-0de4182c47cc4fb89169c4e13f9786bf
Source dataset
uspto-grants-2015_12
Patent number
US09211254B2

Reaction notes

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