Hydrochloric Acid → Sodium hydroxide rebamipide

HRID 1502603Notes

Reaction equation

HRID 1502603 reaction equation
Cl.[CH:2]1[CH:3]=[CH:4][C:5]2[NH:12][C:10](=[O:11])[CH:9]=[C:8]([CH2:13][CH:14]([NH:18][C:19]([C:21]3[CH:22]=[CH:23][C:24]([Cl:27])=[CH:25][CH:26]=3)=[O:20])[C:15]([OH:17])=[O:16])[C:6]=2[CH:7]=1.[OH-].[Na+:29]>O>[OH-:11].[Na+:29].[CH:2]1[CH:3]=[CH:4][C:5]2[NH:12][C:10](=[O:11])[CH:9]=[C:8]([CH2:13][CH:14]([NH:18][C:19]([C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)=[O:20])[C:15]([OH:17])=[O:16])[C:6]=2[CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5042Rebamipide2×HCID 14798Sodium Hydroxide2×

Product 1

HCID 68327531Sodium hydroxide rebamipide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

12 ML of 10 N hydrochloric acid (14.2 g, 0.12 mol), 68 mL of purified water, and 200 mL of a mixture of 2.5% (w/v) PVPK 25+2.5% (w/v) HPMC (TC-5E) were mixed to prepare a hydrochloric acid-HPMC (TC-5E)-PVPK 25 solution. To 700 mL of an aqueous solution of sodium hydroxide which was prepared by adding purified water to 4.4 g of sodium hydroxide (0.11 mol), 20 g of rebamipide (0.054 mol) was added and dissolved with heating to give a sodium hydroxide-rebamipide solution.

Workup

  1. additionby adding
  2. additionwas added
  3. dissolutiondissolved
  4. temperaturewith heating

Sources & evidence

ORD record
ord-28a6021e7a3d4d4a82c5c291882bbb32
Source dataset
uspto-grants-2015_12
Patent number
US09211254B2

Reaction notes

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