Water → tert-butyl N-[isopropyl(2,2,2-trifluoroethylcarbamoyl)amino]carbamate
Reaction equation
[F:1][C:2]([F:6])([F:5])[CH2:3][NH2:4].Cl[C:8](Cl)([O:10]C(=O)OC(Cl)(Cl)Cl)Cl.[CH:19]([NH:22][NH:23][C:24](=[O:30])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])([CH3:21])[CH3:20].O>C(Cl)Cl>[CH:19]([N:22]([C:8](=[O:10])[NH:4][CH2:3][C:2]([F:6])([F:5])[F:1])[NH:23][C:24]([O:25][C:26]([CH3:28])([CH3:27])[CH3:29])=[O:30])([CH3:21])[CH3:20]Participants
Procedure
2,2,2-Trifluoroethanamine (284 mg, 2.87 mmol), TEA (0.8 ml, 5.74 mmol)) in CH2Cl2 (6 mL) were added to the solution of triphosgene (298 mg, 1 mmol) in CH2Cl2 (8 mL) at −40° C. and the reaction mixture was stirred for 30 min tert-Butyl N-(isopropylamino)carbamate (JOC, 2013, 78, 3541-3552.) (500 mg, 2.87 mmol) in CH2Cl2 (4 mL) was then added to the reaction mixture at −40° C. and stirred at ambient temperature—overnight. Water was added to the reaction mixture and it was extracted with CH2Cl2. The organic layer wad washed with brine, dried (Na2SO4), filtered and concentrated to afford the title compound as an off white solid (580 mg, crude): mp 90-94° C.; 1H NMR (400 MHz, DMSO-d6) δ 8.70 (bs, 1H), 6.81 (t, J=6.3, 1H), 3.89-3.80 (m, 2H), 3.11-3.08 (m, 1H), 1.40 (s, 9H), 0.97 (d, J=6.0 Hz, 6H); ESIMS m/z 241.9 ([M-tert-Butyl]+).
Workup
- additionwas then added to the reaction mixture at −40° C.
- extractionwas extracted with CH2Cl2
- washThe organic layer wad washed with brine
- dry with materialdried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-1888b7f5d7e94e25a731db1e96337582
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09210927B2
Reaction notes
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