HCID 86675232, compound → HCID 86675231, compound

HRID 1503057Notes

Reaction equation

HRID 1503057 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:9]([C:28]([F:31])([F:30])[F:29])/[CH:10]=[CH:11]/[C:12]2[CH:13]=[CH:14][C:15]([N:23]3[CH:27]=[N:26][CH:25]=[N:24]3)=[C:16]([CH:22]=2)[C:17]([O:19]CC)=[O:18])[CH:5]=[C:6]([Cl:8])[CH:7]=1>Cl>[Cl:8][C:6]1[CH:5]=[C:4]([CH:9]([C:28]([F:29])([F:31])[F:30])/[CH:10]=[CH:11]/[C:12]2[CH:13]=[CH:14][C:15]([N:23]3[CH:27]=[N:26][CH:25]=[N:24]3)=[C:16]([CH:22]=2)[C:17]([OH:19])=[O:18])[CH:3]=[C:2]([Cl:1])[CH:7]=1

Participants

3

Reactant 1

HCID 86675232HCID 86675232, compound

Product 1

HCID 86675231HCID 86675231, compoundYield 67.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of (E)-ethyl 5-(3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-1-en-1-yl)-2-(1H-1,2,4-triazol-1-yl)benzoate (0.2 g, 0.4 mmol) in 6 N HCl (10 mL) was stirred at 100° C. for 18 h. The reaction was cooled to ambient temperature, resulting in a white solid precipitate. The precipitate was filtered to afford the title compound as a white solid (0.12 g, 60%).

Workup

  1. customresulting in a white solid precipitate
  2. filtrationThe precipitate was filtered

Sources & evidence

ORD record
ord-230a608e2ee34634b98b7c282ba56980
Source dataset
uspto-grants-2015_12
Patent number
US09211281B2

Reaction notes

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