反应详情

温度

80 °C

A mixture of 2-(2-bromophenylthio)-2-methylpropanoate (151 mg, 0.5 mmol), 4-cyanophenyl boronic acid (76 mg, 0.5 mmol), aqueous sodium carbonate solution (2 M, 1 mL), and Pd(PPh3)4 (29 mg, 0.025 mmol) in dioxane (2 mL) was degassed for 15 minutes. The mixture was sealed and heated to 80° C. for 12 hours. The reaction mixture was washed with water, extracted with ethyl acetate, dried (MgSO4), concentrated and purified by chromatography to yield ethyl 2-(4′-cyanobiphenyl-2-ylthio)-2-methylpropanoate (93 mg, 57%).

1. customwas degassed for 15 minutes
2. customThe mixture was sealed
3. washThe reaction mixture was washed with water
4. extractionextracted with ethyl acetate
5. dry with materialdried (MgSO4)
6. concentrationconcentrated
7. custompurified by chromatography