Sodium Carbonate → Ethyl 2-(4'-cyanobiphenyl-2-ylthio)-2-methylpropanoate

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(2-bromophenylthio)-2-methylpropanoate (151 mg, 0.5 mmol), 4-cyanophenyl boronic acid (76 mg, 0.5 mmol), aqueous sodium carbonate solution (2 M, 1 mL), and Pd(PPh3)4 (29 mg, 0.025 mmol) in dioxane (2 mL) was degassed for 15 minutes. The mixture was sealed and heated to 80° C. for 12 hours. The reaction mixture was washed with water, extracted with ethyl acetate, dried (MgSO4), concentrated and purified by chromatography to yield ethyl 2-(4′-cyanobiphenyl-2-ylthio)-2-methylpropanoate (93 mg, 57%).

Provenance & Evidence