Sodium Hydroxide → 2-(2-(6-Cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoic Acid

HRID 1503095Notes

Reaction equation

[CH:1]1([C:4]2[N:9]=[CH:8][C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[S:16][C:17]([CH3:24])([CH3:23])[C:18]([O:20]CC)=[O:19])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.[OH-].[Na+]>CO>[CH:1]1([C:4]2[N:9]=[CH:8][C:7]([C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[S:16][C:17]([CH3:24])([CH3:23])[C:18]([OH:20])=[O:19])=[CH:6][CH:5]=2)[CH2:2][CH2:3]1

Participants

Conditions

Temperature: 60 °C

Procedure

A mixture of ethyl 2-(2-(6-cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoate (0.286 mmol) and aqueous sodium hydroxide solution (1 M, 2 mmol) in methanol is stirred at 60° C. for 12 hours. The reaction mixture is then concentrated, acidified, filtered and the isolated solid purified by to chromatography.

Workup

concentrationThe reaction mixture is then concentrated
filtrationfiltered
customthe isolated solid purified by to chromatography

Sources & evidence

ORD record: ord-9ffd21a163cb48e6b4e0da7568852800
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09212135B2

Reaction notes

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