HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1503095Generated: October 29, 2026
Sodium Hydroxide → 2-(2-(6-Cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoic Acid
https://huagongshe.com/reaction/1503095
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 2-(2-(6-cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoate | HCID 54764233 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(2-(6-Cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoic Acid | HCID 68001060 | — |
Reaction Steps
A mixture of ethyl 2-(2-(6-cyclopropylpyridin-3-yl)phenylthio)-2-methylpropanoate (0.286 mmol) and aqueous sodium hydroxide solution (1 M, 2 mmol) in methanol is stirred at 60° C. for 12 hours. The reaction mixture is then concentrated, acidified, filtered and the isolated solid purified by to chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09212135B2 |
|---|
| Source dataset | uspto-grants-2015_12 |
|---|
| ORD ID | ord-9ffd21a163cb48e6b4e0da7568852800 |
|---|
| Source note | uspto-grants-2015_12 |
|---|
