Sodium Hydroxide → 2-Methyl-2-(2-(pyridin-4-yl)phenylthio)propanoic Acid
Reaction equation
[CH3:1][C:2]([S:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)([CH3:8])[C:3]([O:5]CC)=[O:4].[OH-].[Na+]>CO>[CH3:8][C:2]([S:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:16]1[CH:17]=[CH:18][N:19]=[CH:20][CH:21]=1)([CH3:1])[C:3]([OH:5])=[O:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 60 °C
Procedure
A mixture of ethyl 2-methyl-2-(2-(pyridin-4-yl)phenylthio)propanoate and aqueous sodium hydroxide solution (1 M) in methanol is stirred at 60° C. for 12 hours. The reaction mixture is then concentrated, acidified, filtered and the isolated solid purified by to chromatography.
Workup
- concentrationThe reaction mixture is then concentrated
- filtrationfiltered
- customthe isolated solid purified by to chromatography
Sources & evidence
- ORD record
- ord-acaf84286574495d8b7d30d3ac27e28f
- Source dataset
- uspto-grants-2015_12
- Patent number
- US09212135B2
Reaction notes
Loading…