Hydrazine hydrate (1:1) → HCID 117778387, compound

HRID 1503235Notes

Reaction equation

HRID 1503235 reaction equation
Cl[C:2]1[CH:22]=[CH:21][C:5]([C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([CH:15]3[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]3)=[CH:11][CH:10]=2)=[O:7])=[CH:4][N:3]=1.O.[NH2:24][NH2:25]>C(O)C>[CH:15]1([C:12]2[CH:13]=[CH:14][C:9]([NH:8][C:6](=[O:7])[C:5]3[CH:21]=[CH:22][C:2]([NH:24][NH2:25])=[N:3][CH:4]=3)=[CH:10][CH:11]=2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 117778012HCID 117778012, compound

Product 1

HCID 117778387HCID 117778387, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

6-Chloro-N-(4-cyclohexylphenyl)nicotinamide (0.40 g) and hydrazine monohydrate (3 mL) were suspended in ethanol (6 mL), and the suspension was heated to reflux for 2 hours. The reaction solution was concentrated under reduced pressure, and the obtained solid was then collected by filtration and washed with an ethyl acetate-ethanol mixed solvent. The solid was dried under reduced pressure to obtain the title compound (0.39 g) as a white solid (yield: 99%).

Workup

  1. temperaturethe suspension was heated
  2. temperatureto reflux for 2 hours
  3. concentrationThe reaction solution was concentrated under reduced pressure
  4. filtrationthe obtained solid was then collected by filtration
  5. washwashed with an ethyl acetate-ethanol mixed solvent
  6. customThe solid was dried under reduced pressure

Sources & evidence

ORD record
ord-4889eb8ed214453d88a0c38bd9600fe3
Source dataset
uspto-grants-2015_12
Patent number
US09212170B2

Reaction notes

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