HCID 69198469, compound → HCID 71765701, compound

HRID 1503236Notes

Reaction equation

HRID 1503236 reaction equation
[CH:1]1([C:7]2[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:23])[C:15]3[CH:20]=[CH:19][C:18]([NH:21][NH2:22])=[N:17][CH:16]=3)=[CH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O:26][CH:27]=[C:28]1[C:32](=O)[O:31][C:30]([CH3:34])=[N:29]1)C>C(O)C>[C:30]([NH:29][C:28]1[C:27](=[O:26])[N:21]([C:18]2[CH:19]=[CH:20][C:15]([C:14]([NH:13][C:10]3[CH:9]=[CH:8][C:7]([CH:1]4[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]4)=[CH:12][CH:11]=3)=[O:23])=[CH:16][N:17]=2)[NH:22][CH:32]=1)(=[O:31])[CH3:34]

Participants

4

Reactant 2

HCID 69198469HCID 69198469, compoundHCID 117778387HCID 117778387, compound

Product 1

HCID 71765701HCID 71765701, compoundYield 5.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-(4-Cyclohexylphenyl)-6-hydrazinonicotinamide (0.20 g) and 4-(ethoxymethylene)-2-methyl-1,3-oxazol-5(4H)-one (0.12 g) were dissolved in ethanol (30 mL), and the solution was stirred at room temperature for 1.5 hours. The solvent was distilled off under reduced pressure, and diisopropyl ether was added to the residue. The deposited solid was collected by filtration and washed with diisopropyl ether. The solid was dried under reduced pressure to obtain the title compound (0.015 g) as a white solid (yield: 5.5%).

Workup

  1. distillationThe solvent was distilled off under reduced pressure, and diisopropyl ether
  2. additionwas added to the residue
  3. filtrationThe deposited solid was collected by filtration
  4. washwashed with diisopropyl ether
  5. customThe solid was dried under reduced pressure

Sources & evidence

ORD record
ord-48e4440e87e84b1f9472eb08a16fb575
Source dataset
uspto-grants-2015_12
Patent number
US09212170B2

Reaction notes

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