反应详情

6-Chloro-N-[4-(trifluoromethyl)phenyl]nicotinamide (0.49 g) and hydrazine monohydrate (4 mL) were suspended in ethanol (8 mL), and the suspension was heated to reflux for 15 hours. The reaction solution was concentrated under reduced pressure, and the obtained solid was then collected by filtration and washed with ethyl acetate. The solid was dried under reduced pressure to obtain the title compound (0.31 g) as a white solid (yield: 64%).

1. temperaturethe suspension was heated
2. temperatureto reflux for 15 hours
3. concentrationThe reaction solution was concentrated under reduced pressure
4. filtrationthe obtained solid was then collected by filtration
5. washwashed with ethyl acetate
6. customThe solid was dried under reduced pressure