反应详情

To a solution of 3-chloro-N-[3-(hydroxymethyl)-1-adamantyl]benzamide (200 mg, 0.63 mmol) in DCM (15 mL) was added PCC (200 mg, 0.93 mmol) in one portion and the reaction mixture was stirred at room temperature for two hours. The reaction mixture was then filtered through a pad of silica gel and the filtrate was concentrated under reduced pressure to give 200 mg (100%) of crude title compound, 3-chloro-N-(3-formyl-1-adamantyl)benzamide, as a brown oil. ESI-MS m/z: 318 (M+H)+.

1. filtrationThe reaction mixture was then filtered through a pad of silica gel
2. concentrationthe filtrate was concentrated under reduced pressure