3-chloro-N-[3-(hydroxymethyl)-1-adamantyl]benzamide → 3-chloro-N-(3-formyl-1-adamantyl)benzamide

Participants

Reaction Steps

To a solution of 3-chloro-N-[3-(hydroxymethyl)-1-adamantyl]benzamide (200 mg, 0.63 mmol) in DCM (15 mL) was added PCC (200 mg, 0.93 mmol) in one portion and the reaction mixture was stirred at room temperature for two hours. The reaction mixture was then filtered through a pad of silica gel and the filtrate was concentrated under reduced pressure to give 200 mg (100%) of crude title compound, 3-chloro-N-(3-formyl-1-adamantyl)benzamide, as a brown oil. ESI-MS m/z: 318 (M+H)+.

Provenance & Evidence