HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Acetate → 1-(Pyridazin-3-yl)ethan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Acetate | HCID 517044 | — |
| Reactant | N-methoxy-N-methylpyridazine-3-carboxamide | HCID 58197546 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(Pyridazin-3-yl)ethan-1-ol | HCID 15197511 | 281.9% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A suspension of compound 2 (170 mg, 0.4 mmol), compound 2A (112 mg, 0.44 mmol), PdCl2(dppf)2 (50 mg, 0.08 mmol) and KOAc (118 mg, 1.2 mmol) in anhydrous 1,4-dioxane (6 mL) was heated at 100° C. for 60 min in a CEM microwave reactor. The mixture was concentrated in vacuo and the residue was purified by preparative TLC (eluent:petroleum ether:ethyl acetate=3:1) to give compound 3 (140 mg, 70%, 67% purity) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09212153B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-af32eae46ade4dfa883d25c80222f3fd |
| Source note | uspto-grants-2015_12 |