反应详情

A suspension of the product of Example 13A (6.3 g, 18.7 mmol) and Raney nickel (2.0 g) in 300 mL methanol was stirred under hydrogen at ambient temperature for 5 hours. The mixture was filtered through diatomaceous earth and the filtrate was concentrated. The residue was purified by flash chromatography on silica gel (200-300 mesh) eluting with a gradient of 2/1 to 1/1 petroleum/ethyl acetate to give the title compound.

1. filtrationThe mixture was filtered through diatomaceous earth
2. concentrationthe filtrate was concentrated
3. customThe residue was purified by flash chromatography on silica gel (200-300 mesh)
4. washeluting with a gradient of 2/1 to 1/1 petroleum/ethyl acetate