Tert-butyl 4-(3-methoxy-4-nitrophenyl)piperazine-1-carboxylate → Tert-butyl 4-(4-amino-3-methoxyphenyl)piperazine-1-carboxylate

Participants

Reaction Steps

A suspension of the product of Example 13A (6.3 g, 18.7 mmol) and Raney nickel (2.0 g) in 300 mL methanol was stirred under hydrogen at ambient temperature for 5 hours. The mixture was filtered through diatomaceous earth and the filtrate was concentrated. The residue was purified by flash chromatography on silica gel (200-300 mesh) eluting with a gradient of 2/1 to 1/1 petroleum/ethyl acetate to give the title compound.

Provenance & Evidence