4-Bromo-2-fluoro-1-nitrobenzene → HCID 69435785, compound

HRID 1503814Notes

Reaction equation

HRID 1503814 reaction equation
[CH3:1][S-:2].[Na+].[Br:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[C:7](F)[CH:6]=1>O.CN(C)C=O>[Br:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[C:7]([S:2][CH3:1])[CH:6]=1

Participants

5

Reactant 2

HCID 27833624-Bromo-2-fluoro-1-nitrobenzeneHCID 4378561Sodium methanethiolate

Product 1

HCID 69435785HCID 69435785, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A solution of sodium methanethiolate (2.25 g, 70.1 mmol) in water (50 mL) was added dropwise to a solution of 4-bromo-2-fluoro-1-nitrobenzene (6.42 g, 29.2 mmol) in N,N-dimethylformamide (150 mL) at 0° C. and the mixture was stirred for 1 hour. The mixture was filtered and the solid washed with water (3×150 mL) to give the title compound.

Workup

  1. filtrationThe mixture was filtered
  2. washthe solid washed with water (3×150 mL)

Sources & evidence

ORD record
ord-32ee9bbb5ad440369b95bf9a317467cd
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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