HCID 86725376, compound → HCID 69676295, compound

HRID 1503820Notes

Reaction equation

HRID 1503820 reaction equation
C([N:8](CC1C=CC=CC=1)[C:9]1[C:14]([F:15])=[CH:13][C:12]([N:16]2[CH2:21][CH2:20][N:19]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:18][CH2:17]2)=[C:11]([F:29])[CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[NH2:8][C:9]1[C:14]([F:15])=[CH:13][C:12]([N:16]2[CH2:17][CH2:18][N:19]([C:22]([O:24][C:25]([CH3:27])([CH3:26])[CH3:28])=[O:23])[CH2:20][CH2:21]2)=[C:11]([F:29])[CH:10]=1

Participants

4

Reactant 1

HCID 86725376HCID 86725376, compound

Product 1

HCID 69676295HCID 69676295, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of the product of Example 15B (4 g, 8 mmol) in methanol (100 mL) was added 10% palladium on carbon (400 mg). The mixture was stirred at room temperature under hydrogen for 16 hours. The catalyst was filtered off and the filtrate was concentrated to give the title compound. MS: 314 (M+H+).

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-646f4728bc15410d8a1ad0adfff08e21
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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