Hydrazine hydrate (1:1) → HCID 86725377, compound

HRID 1503821Notes

Reaction equation

HRID 1503821 reaction equation
[C:1]([C:4]1[C:5]([NH:13][C:14]2[C:19]([F:20])=[CH:18][C:17]([N:21]3[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22]3)=[C:16]([F:34])[CH:15]=2)=[N:6][C:7]([S:11][CH3:12])=[N:8][C:9]=1Cl)(=[O:3])[NH2:2].O.[NH2:36][NH2:37]>O1CCOCC1>[C:1]([C:4]1[C:5]([NH:13][C:14]2[C:19]([F:20])=[CH:18][C:17]([N:21]3[CH2:26][CH2:25][N:24]([C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[CH2:23][CH2:22]3)=[C:16]([F:34])[CH:15]=2)=[N:6][C:7]([S:11][CH3:12])=[N:8][C:9]=1[NH:36][NH2:37])(=[O:3])[NH2:2]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86725378HCID 86725378, compound

Product 1

HCID 86725377HCID 86725377, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a solution of the product of Example 15D (3.53 mg, 0.69 mmol) in 1,4-dioxane (5 mL) was added hydrazine hydrate (0.3 mL). After stirring at ambient temperature for 4 hours, the mixture was concentrated. The residue was washed with hexane and dried under vacuum to give the crude title compound, which was used in the next step without further purification (281 mg, 80%). MS: 511 (M+H+).

Workup

  1. concentrationthe mixture was concentrated
  2. washThe residue was washed with hexane
  3. customdried under vacuum

Sources & evidence

ORD record
ord-16385865b81e4a22b28c090ba3629622
Source dataset
uspto-grants-2015_12
Patent number
US09212192B2

Reaction notes

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